The A417 both ways is blocked due to a crash and fuel spillage near Chalk Hill.
Thames Valley Police spokeswoman Connie Primer said officers were called at 10.45am to the collision between two cars.
It is believed one female sustained injuries that are not thought to be life-threatening.
There were initial fears fuel was leaking from one vehicle but the problem has been rectified.
Both vehicles are awaiting recovery and as such the road is currently blocked.
Get the latest on this incident with our traffic page
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