The M40 between Thame and Watlington was blocked after a van crashed at about 7.05am yesterday.
Thames Valley Police said the vehicle had been travelling on the northbound carriageway.
Emergency services closed off the route from junction six to seven in both directions, but opened all lanes at about 7.45am.
Police spokeswoman Charlotte Redman said someone had been injured, but could not say how badly. There were three miles of tailbacks as a result of the closure.
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