OXFORD United will visit Newport County in the Carabao Cup second round later this month.
The draw was regionalised, but unseeded, with the Premier League sides not in European competition entering the fray.
United reached the second round thanks to a 2-0 home win over Coventry City on Tuesday night.
And a tie away to a Sky Bet League Two side gives them a fighting chance of reaching the third round for the first time since 2002.
United's last visit to Rodney Parade was in April 2016, when they ground out a 1-1 draw in the run-in to their promotion-clinching season under Michael Appleton.
The ties are due to be played in the week commencing August 27.
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